Methotrexate and other Disease Modifying Antirheumatic Drugs (DMARDs)
Methotrexate is one of the few drugs that have been proven to stop the progression of the disease. Combined with other drugs, it also reduces the amount of joint damage. But side effects of this medication are common, including stomach irritation, skin rash, and liver damage. Thus, they might not be appropriate for pregnant women, and sometimes, patients need to change their meds to find the most suitable ones.
Methotrexate is a nonbiological DMARD. There are others, known as biological DMARDs, which are newer versions of the drug. They are apparently more effective in combination with glucocorticoids and other painkillers. Still, the combination might have varying results in different patients.